Recently, there has been increased interest in launching cosmetic products containing peptides to prevent or reduce skin aging in skincare cosmetics. The peptides can be extracted from several sources including plants, animals, or microorganisms, or can be produced synthetically.

Peptides may be biologically active and have the potential to interact with skin. Thus, in line with the requirements stipulated under the EU Cosmetics Product Regulation ((EC) No 1223/2009) (EU, 2009), their safety must be established by selecting an appropriate Point of Departure (PoD) for systemic toxicity and a sufficiently high Margin of Safety (MoS) under cosmetic product use conditions.