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For hazards of highest concern (e.g., carcinogenicity, mutagenicity, reproductive toxicity), the European harmonised classification and labelling (CLH) system is set up to ensure an adequate risk management. Harmonized classifications are listed in Annex VI of the of the Classification, Labelling and Packaging (CLP) legislation and should be applied by all manufacturers, importers, or downstream users […]
Skin sensitisation is one of the key adverse health effects to be addressed in the safety assessment of cosmetic ingredients. In the past, guinea pig assays such as the Guinea pig maximization test (GPMT) were mostly used for skin sensitisation hazard identification. In an attempt to reduce the use of experimental animals and have better […]
The European Commission is looking for comments on its intention to update REACH data requirements for identifying and assessing endocrine disruptors (EDs). The Competent Authorities for REACH and the CLP Expert Group on Endocrine Disrupters recently published their initial reflections on the update of the REACH Annexes to include data requirements on endocrine disruption (Annex […]
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