Evaluation of in vitro assays for the assessment of the skin sensitisation hazard of functional polysiloxanes and silanes
A published research programme investigating the skin sensitisation potential of a group of functional polysiloxanes and silanes in vivo and in vitro is an instructive example of what can happen in ‘real life’ when testing a group of chemical substances that seemingly belong to the same class of chemicals for skin sensitisation
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Principles underlying the next generation risk assessment approach (NGRA)
Next Generation Risk Assessment (NGRA) is defined as an exposure-led, hypothesis-driven risk assessment approach that integrates in silico, in chemico and in vitro approaches.
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