EFSA/ECHA (2018) guidance for the identification of endocrine disruptors (ED): looking back after the first 3 years of implementation

News from ECHA’s Committee for Risk Assessment (RAC) – Adoption of Opinion on Harmonised Classification and Labelling for MWCNTs

For hazards of highest concern (e.g., carcinogenicity, mutagenicity, reproductive toxicity), the European harmonised classification and labelling (CLH) system is set up to ensure an adequate risk management. Harmonized classifications are listed in Annex VI of the of the Classification, Labelling and Packaging (CLP) legislation and should be applied by all manufacturers, importers, or downstream users […]

Next generation risk assessment (NGRA) for skin sensitisation: Case studies with resorcinol and propyl paraben

Skin sensitisation is one of the key adverse health effects to be addressed in the safety assessment of cosmetic ingredients. In the past, guinea pig assays such as the Guinea pig maximization test (GPMT) were mostly used for skin sensitisation hazard identification. In an attempt to reduce the use of experimental animals and have better […]

Initial reflections on a way forward to update the REACH Annexes in relation to endocrine disruption properties – OPEN FOR FEEDBACK UNTIL 16 NOVEMBER

The European Commission is looking for comments on its intention to update REACH data requirements for identifying and assessing endocrine disruptors (EDs). The Competent Authorities for REACH and the CLP Expert Group on Endocrine Disrupters recently published their initial reflections on the update of the REACH Annexes to include data requirements on endocrine disruption (Annex […]

Ms. Celine De Roy

Ms. Celine De Roy is a Research Associate at ToxMinds. She provides (eco)toxicology, regulatory and consortium management support for various project. Prior to joining ToxMinds, Celine completed a 1-year training on cell culture, biochemical tests and flow cytometry to achieve her master thesis on the subject of “Characterization of mesotheliomagenic macrophage immunosuppressive activity: development of […]

Implementing Regulation (EU/2020/1435) on the duties placed on registrants to update their registrations along with proposed deadlines under the EU REACH Regulation

Article 22(1) of Regulation (EC) No 1907/2006 (REACH regulation) places a responsibility on registrants (whether individual registrants or the lead registrant and other members of a joint submission) to update their registrations without undue delay with relevant new information and submit them to the European Chemicals Agency (ECHA). Information counts as ‘new’ if the registrant […]