Assessing cosmetic ingredients for endocrine disrupting properties

EFSA/ECHA (2018) guidance for the identification of endocrine disruptors (ED): looking back after the first 3 years of implementation

The importance of having a solid PC data package to support human health/environmental risk assessment and read across under REACH

Using (Q)SAR and read across to evaluate the toxicological risks of data-poor drug impurities and extractables/leachables

News from ECHA’s Committee for Risk Assessment (RAC) – Adoption of Opinion on Harmonised Classification and Labelling for MWCNTs

For hazards of highest concern (e.g., carcinogenicity, mutagenicity, reproductive toxicity), the European harmonised classification and labelling (CLH) system is set up to ensure an adequate risk management. Harmonized classifications are listed in Annex VI of the of the Classification, Labelling and Packaging (CLP) legislation and should be applied by all manufacturers, importers, or downstream users […]

Next generation risk assessment (NGRA) for skin sensitisation: Case studies with resorcinol and propyl paraben

Skin sensitisation is one of the key adverse health effects to be addressed in the safety assessment of cosmetic ingredients. In the past, guinea pig assays such as the Guinea pig maximization test (GPMT) were mostly used for skin sensitisation hazard identification. In an attempt to reduce the use of experimental animals and have better […]

Initial reflections on a way forward to update the REACH Annexes in relation to endocrine disruption properties – OPEN FOR FEEDBACK UNTIL 16 NOVEMBER

The European Commission is looking for comments on its intention to update REACH data requirements for identifying and assessing endocrine disruptors (EDs). The Competent Authorities for REACH and the CLP Expert Group on Endocrine Disrupters recently published their initial reflections on the update of the REACH Annexes to include data requirements on endocrine disruption (Annex […]

Implementing Regulation (EU/2020/1435) on the duties placed on registrants to update their registrations along with proposed deadlines under the EU REACH Regulation

Article 22(1) of Regulation (EC) No 1907/2006 (REACH regulation) places a responsibility on registrants (whether individual registrants or the lead registrant and other members of a joint submission) to update their registrations without undue delay with relevant new information and submit them to the European Chemicals Agency (ECHA). Information counts as ‘new’ if the registrant […]

The European Commission’s Joint Research Centre (EC- JRC) tender to collect and organise mechanistic knowledge related to the toxicological effects on target organs observed in animal models after repeated exposure to chemicals

In recent years, considerable progress has been made towards promoting the development, validation, acceptance and use of alternative approaches to animal experimentation in life sciences. A range of alternative methods have been validated and accepted by regulatory bodies across the world. However, the validation and acceptance of animal alternative methods allowing to assess systemic toxicity […]

Ecotoxicological assessment of pharmaceuticals and personal care products using predictive toxicology approaches

With their widespread and ever increasing use, active pharmaceutical ingredients (API) and personal care products (PCP) represent contaminants of emerging concern for the aquatic and terrestrial environments. Today, numerous countries worldwide have issued regulations and guidance to cover the environmental risk assessment of these substances, but in many cases the necessary hazard data is missing […]

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