• Industries
    • Chemicals
    • Cosmetic & Consumer Products
    • Pharmaceuticals & Medical Devices
    • Biocides
    • Green biotechnology
  • Services
    • Chemical and Product Safety
    • Regulatory Strategy and Compliance
    • QSAR Modelling
    • New Approach Methodologies
    • Endocrine disruption
    • Product Stewardship
  • Team
    • Team
    • Collaborations
  • Insights
  • Work
    • Publications
    • Cases
  • Careers
  • Industries
    • Chemicals
    • Cosmetic & Consumer Products
    • Pharmaceuticals & Medical Devices
    • Biocides
    • Green biotechnology
  • Services
    • Chemical and Product Safety
    • Regulatory Strategy and Compliance
    • QSAR Modelling
    • New Approach Methodologies
    • Endocrine disruption
    • Product Stewardship
  • Team
    • Team
    • Collaborations
  • Insights
  • Work
    • Publications
    • Cases
  • Careers
  • You are here:
  • Home
  • Insights
  • 13th SETAC Scientific Symposium: Extrapolation of effects across biological levels

13th SETAC Scientific Symposium: Extrapolation of effects across biological levels

The 13th SETAC Scientific Symposium entitled ‘’Extrapolation of Effects Across Biological Levels: Challenges to Implement Scientific Approaches in Regulations’’ took place in Brussels on the 23rd and 24th of October. The symposium discussed extrapolation tools for environmental risk assessment purposes across different biological levels, and more importantly, how to bring those models to regulatory conformity. 

The existing applications and planned new approaches were reviewed in the context of the EU REACH, biocides, pesticides and pharmaceuticals legislations. The speakers presented the extrapolation methods involved in evaluating sub-individual to individual levels (AOPs, TK-TD), individual to population levels (ordinary differential equation models, AQUATOX, CASM) and population to landscape levels (Food-web, Ecosystem models). Finding the link between these approaches will be an important step forward in improving environmental risk assessment.

Extrapolation methods are one of the tools to reduce animal toxicity testing. Developments in mechanistic ecological models aim to replace the traditional approach of using safety factors and L(E)C50 values with models presenting more realistic scenarios. This type of model predictions will also help to better define uncertainties around risk. How to bring existing and newer models to the level of regulatory acceptance remains one of the critical questions. To this end, case studies were presented as one of the best ways to communicate scientific advances. Because of the growing regulatory needs and rapid scientific developments, more cross-disciplinary meetings on the topic will take place in the near future.

While a number of models have already been successfully applied to the aquatic environment, there is less interest given to models of terrestrial ecosystems. This subject will be one of the focuses for the next SETAC conference taking place in Helsinki in May 2019.

Author





Email:

MORE INSIGHTS
  • ECHA Public activities coordination tool

  • Update on the development of a regulatory framework for developmental neurotoxicity testing with specific focus on non-animal testing approaches

Conduct of a hands-on training on the use of in silico tools in chemical hazard assessment

ECHA Public activities coordination tool

Next thumb
Scroll

 

ToxMinds are specialised in ensuring product safety and compliance.

We are passionate about toxicology and how emerging scientific developments can be utilised to support our customers in bringing safe, regulatory compliant and sustainable products to the marketplace.

 

 

 

 

Belgium
ToxMinds BVBA
Avenue de Broqueville 116
B-1200 Brussels, Belgium

VAT BE 0877.628.383

Tel: +32 (0)2 762 9145
Email:

 

 

 

 

India
ToxMinds India Consulting Pvt. Ltd.
1015 Brigade IRV Centre, 10th Floor
Whitefield, Bangalore 560066, India

 

 
Email:

 

 

 

 

 

LinkedIN
Copyright and disclaimer | Data privacy
  • Home
  • Industries
  • Services
  • Team
  • Insights
  • Work
  • Careers