Identification of safe exposure levels of chemicals used in cosmetic and consumer product ingredients

ToxMinds supported a large multinational consumer product company in the context of an internal chemical safety review programme by developing standardised hazard assessments.

In the context of this programme, we collated and assessed information pertaining to the local and systemic toxicity of the chemical in question (including skin sensitisation, genotoxicity, carcinogenicity, developmental and reproductive toxicity); determined non-animal based strategies how to fill endpoint data gaps (e.g., grouping and SAR-supported read-across approaches); identified the most appropriate POD study for NOAEL derivation, and we determined for each chemical a safe exposure level (SEL) for consumer product use by application of an appropriate safety factor. The chemical-specific assessment was completed by drafting a hazard summary template, which included a summary of the available data for each endpoint, a description and justification of the POD study as well as the SEL, including justification of the safety factor. Over six years, we developed more than 750 hazard assessments for chemicals used in cosmetics and other types of consumer products as part of this programme.