Initial reflections on a way forward to update the REACH Annexes in relation to endocrine disruption properties – OPEN FOR FEEDBACK UNTIL 16 NOVEMBER

The European Commission is looking for comments on its intention to update REACH data requirements for identifying and assessing endocrine disruptors (EDs). The Competent Authorities for REACH and the CLP Expert Group on Endocrine Disrupters recently published their initial reflections on the update of the REACH Annexes to include data requirements on endocrine disruption (Annex […]
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Implementing Regulation (EU/2020/1435) on the duties placed on registrants to update their registrations along with proposed deadlines under the EU REACH Regulation

Article 22(1) of Regulation (EC) No 1907/2006 (REACH regulation) places a responsibility on registrants (whether individual registrants or the lead registrant and other members of a joint submission) to update their registrations without undue delay with relevant new information and submit them to the European Chemicals Agency (ECHA). Information counts as ‘new’ if the registrant […]
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The European Commission’s Joint Research Centre (EC- JRC) tender to collect and organise mechanistic knowledge related to the toxicological effects on target organs observed in animal models after repeated exposure to chemicals

In recent years, considerable progress has been made towards promoting the development, validation, acceptance and use of alternative approaches to animal experimentation in life sciences. A range of alternative methods have been validated and accepted by regulatory bodies across the world. However, the validation and acceptance of animal alternative methods allowing to assess systemic toxicity […]
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Nanomaterials in cosmetics – The next priority of the Commission?

Since a number of new developments have taken place in the area of nanomaterial safety research, the EC Scientific Committee on Consumer Safety (SCCS) has updated its Guidance in October 2019 to ensure compliance of nanomaterials intended for use as cosmetic ingredients under the current EU legislation (EC No 1223/2009). We have provided a summary […]
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Requirement of second species testing for evaluating developmental toxicity potential

Over the last decade, there has been ongoing debate on the regulatory requirement of a second-species testing requirement to identify developmental toxicity. A recent article by Braakhuis et al. (2019) has questioned the reproducibility of developmental toxicity results and the comparison approach using NOAELs. The current insight attempts to present the state-of-the-art information on the ongoing discussion.
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Mr. Pragnesh Panchamvedi

Mr. Pragnesh Panchamvedi, a Consultant at ToxMinds India Consulting Pvt. Ltd., is a regulatory toxicology professional with 7 years’ industry and research experience in human health risk assessment of chemicals, cosmetics and consumer products. He has an extensive experience in safety assessment as well as regulatory compliance of cosmetics and consumer products as per global […]
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