The European Commission’s Joint Research Centre (EC- JRC) tender to collect and organise mechanistic knowledge related to the toxicological effects on target organs observed in animal models after repeated exposure to chemicals
In recent years, considerable progress has been made towards promoting the development, validation, acceptance and use of alternative approaches to […]
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Requirement of second species testing for evaluating developmental toxicity potential
Over the last decade, there has been ongoing debate on the regulatory requirement of a second-species testing requirement to identify developmental toxicity. A recent article by Braakhuis et al. (2019) has questioned the reproducibility of developmental toxicity results and the comparison approach using NOAELs. The current insight attempts to present the state-of-the-art information on the ongoing discussion.
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Severity of eye effects caused by accidental exposure to detergent and cleaning products
A most interesting study concerning the severity of eye effects caused by accidental exposure to detergent and cleaning product has recently been published by Scazzola et al., 2019. The study investigated the predictivity of a product’s classification for eye hazard following reported accidental human exposures to common household detergent and cleaning products.
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Inhalation exposure and risk assessment associated with the release of VOC, SVOC and particulates from scented candles
ToxMinds assessed consumer exposures and risks associated with the release of volatile organic compounds, including benzene, formaldehyde and naphthalene from scented candles.
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Identification of hazards associated with non-intentionally added substances in a food contact polymer
ToxMinds was tasked by a petrochemical company to assess the toxicological hazard of and derive MRLs for non-intentionally added substances in a food contact polymer.
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Development of permissible daily exposure levels of impurities present in pharmaceutical products
ToxMinds is a key resource to a major multinational biopharmaceutical company on the safety assessment of extractables & leachables and manufacturing impurities ending up in the medicinal product.
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Human health risk assessment of a biocidal product line for due diligence purposes
ToxMinds supported the acquisition of a biocidal product line by a multinational consumer product company by demonstrating the safety of the products for children and adults under in-use conditions.
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Feasibility screening of new molecules to be used in cosmetic applications
ToxMinds supports a large, multinational cosmetic product manufacturer in prioritising new molecules for use in cosmetic applications from a consumer safety point of view.
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Evaluation of skin sensitisation potential of a class of functionalised chemicals on the basis of in silico, in vitro and in vivo data
ToxMinds assessed and evaluated the skin sensitisation potential of functionalised chemicals on the basis of in silico, in vitro and in vivo data.
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Identification of safe exposure levels of ingredients used in cosmetic and consumer products
ToxMinds supported a large multinational consumer product company in the context of an internal chemical safety review programme by developing standardised hazard assessments.
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Update on the development of a regulatory framework for developmental neurotoxicity testing with specific focus on non-animal testing approaches
Reports of developmental neurotoxicity (DNT) incidences have become increasing over the last 2-3 decades, triggering the need for higher focus on this endpoint and an efficient, tiered testing approach to allow identifying developmental neurotoxicants.
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Application of in silico and TTC based decision tree for safety assessment of botanicals
Safety assessment of botanicals has always been a challenge, not only due to the difficulties in defining them analytically, but also due to data gaps in traditional toxicology endpoints.
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