Next generation risk assessment (NGRA) for skin sensitisation: Case studies with resorcinol and propyl paraben

Skin sensitisation is one of the key adverse health effects to be addressed in the safety assessment of cosmetic ingredients. […]

Alternatives to the use of vertebrate animals in ecotoxicity testing – Progress so far

There is a growing need for alternatives to the use of vertebrate animals in the hazard assessment of chemicals. Many […]

Adopting New Approach Methodologies (NAM) in the next generation risk assessment (NGRA)

The term “new approach methodologies” (NAMs) has been emerged as a descriptive reference to any non-animal-based approaches that can be used to provide information in the context of chemical hazard and risk assessment. These new approaches include integrated approaches to testing and assessment (IATAs), defined approaches for data interpretation, and performance-based evaluation of test methods.

Inhalation exposure and risk assessment associated with the release of VOC, SVOC and particulates from scented candles

ToxMinds assessed consumer exposures and risks associated with the release of volatile organic compounds, including benzene, formaldehyde and naphthalene from scented candles.

Identification of hazards associated with non-intentionally added substances in a food contact polymer

ToxMinds was tasked by a petrochemical company to assess the toxicological hazard of and derive MRLs for non-intentionally added substances in a food contact polymer.

Development of permissible daily exposure levels of impurities present in pharmaceutical products

ToxMinds is a key resource to a major multinational biopharmaceutical company on the safety assessment of extractables & leachables and manufacturing impurities ending up in the medicinal product.

Human health risk assessment of a biocidal product line for due diligence purposes

ToxMinds supported the acquisition of a biocidal product line by a multinational consumer product company by demonstrating the safety of the products for children and adults under in-use conditions.

Feasibility screening of new molecules to be used in cosmetic applications

ToxMinds supports a large, multinational cosmetic product manufacturer in prioritising new molecules for use in cosmetic applications from a consumer safety point of view.

Evaluation of skin sensitisation potential of a class of functionalised chemicals on the basis of in silico, in vitro and in vivo data

ToxMinds assessed and evaluated the skin sensitisation potential of functionalised chemicals on the basis of in silico, in vitro and in vivo data.

Identification of safe exposure levels of ingredients used in cosmetic and consumer products

ToxMinds supported a large multinational consumer product company in the context of an internal chemical safety review programme by developing standardised hazard assessments.

New Approach Methodologies

Update on the development of a regulatory framework for developmental neurotoxicity testing with specific focus on non-animal testing approaches

Reports of developmental neurotoxicity (DNT) incidences have become increasing over the last 2-3 decades, triggering the need for higher focus on this endpoint and an efficient, tiered testing approach to allow identifying developmental neurotoxicants.

Evaluation of in vitro assays for the assessment of the skin sensitisation hazard of functional polysiloxanes and silanes

A published research programme investigating the skin sensitisation potential of a group of functional polysiloxanes and silanes in vivo and in vitro is an instructive example of what can happen in ‘real life’ when testing a group of chemical substances that seemingly belong to the same class of chemicals for skin sensitisation

Principles underlying the next generation risk assessment approach (NGRA)

Next Generation Risk Assessment (NGRA) is defined as an exposure-led, hypothesis-driven risk assessment approach that integrates in silico, in chemico and in vitro approaches.

Read-across – State of the art and next level!

In light of the limitations of existing non-animal based hazard assessment methodologies particularly for systemic endpoints, read-across is currently considered to be the most applicable strategy in the short- to medium-term in support of innovation.