Ms. Avneet Kaur Suri

Conduct of a hands-on training on the use of in silico tools in chemical hazard assessment

In collaboration with Center for Alternatives to Animal Testing (CAAT), ToxMinds conducted a 2-day hands-on training on the use of in silico tools in wider context of chemical hazard assessment.

Science advocacy to prevent onerous classification of a chemical substance for acute inhalation toxicity

ToxMinds developed the technical argumentation and science advocacy strategy to prevent an onerous, scientifically unjustified classification & labeling (CLH) proposal

Establishing health-based exposure limits (PDE) for pharmaceutical actives

ToxMinds established, in line with EMA guidance, permitted daily exposures for more than 30 active pharmaceutical ingredients to allow managing any API residues in case of shared facility manufacturing arrangement.

Consortium management and technical support to European REACH and Biocides consortia

ToxMinds is the consortium management organisation and technical lead consultancy for 3 REACH and 1 Biocides consortia

REACH strategy and registration support to chemical manufacturers

With more than 250 REACH registrations over the last 8 years, ToxMinds is trusted by its clients in the REACH registration process.

Inhalation exposure and risk assessment associated with the release of VOC, SVOC and particulates from scented candles

ToxMinds assessed consumer exposures and risks associated with the release of volatile organic compounds, including benzene, formaldehyde and naphthalene from scented candles.

Identification of hazards associated with non-intentionally added substances in a food contact polymer

ToxMinds was tasked by a petrochemical company to assess the toxicological hazard of and derive MRLs for non-intentionally added substances in a food contact polymer.

Development of permissible daily exposure levels of impurities present in pharmaceutical products

ToxMinds is a key resource to a major multinational biopharmaceutical company on the safety assessment of extractables & leachables and manufacturing impurities ending up in the medicinal product.

Human health risk assessment of a biocidal product line for due diligence purposes

ToxMinds supported the acquisition of a biocidal product line by a multinational consumer product company by demonstrating the safety of the products for children and adults under in-use conditions.

Feasibility screening of new molecules to be used in cosmetic applications

ToxMinds supports a large, multinational cosmetic product manufacturer in prioritising new molecules for use in cosmetic applications from a consumer safety point of view.

Evaluation of skin sensitisation potential of a class of functionalised chemicals on the basis of in silico, in vitro and in vivo data

ToxMinds assessed and evaluated the skin sensitisation potential of functionalised chemicals on the basis of in silico, in vitro and in vivo data.

Identification of safe exposure levels of ingredients used in cosmetic and consumer products

ToxMinds supported a large multinational consumer product company in the context of an internal chemical safety review programme by developing standardised hazard assessments.

Ms. Daniela Jeronimo Roque

Ms. Daniela Geronimo Roque is a Senior Consultant at ToxMinds BVBA, with 7 years of experience in human and environmental exposure modelling for […]

Ms. Sanghamitra Mishra

Mr. Sabyasachi Chakraborty

Dr. Monica Autiero

Dr. Francesca Tencalla

Dr. Thomas Petry

Update on the development of a regulatory framework for developmental neurotoxicity testing with specific focus on non-animal testing approaches

Reports of developmental neurotoxicity (DNT) incidences have become increasing over the last 2-3 decades, triggering the need for higher focus on this endpoint and an efficient, tiered testing approach to allow identifying developmental neurotoxicants.

Application of in silico and TTC based decision tree for safety assessment of botanicals

Safety assessment of botanicals has always been a challenge, not only due to the difficulties in defining them analytically, but also due to data gaps in traditional toxicology endpoints.

Evaluation of in vitro assays for the assessment of the skin sensitisation hazard of functional polysiloxanes and silanes

A published research programme investigating the skin sensitisation potential of a group of functional polysiloxanes and silanes in vivo and in vitro is an instructive example of what can happen in ‘real life’ when testing a group of chemical substances that seemingly belong to the same class of chemicals for skin sensitisation

Principles underlying the next generation risk assessment approach (NGRA)

Next Generation Risk Assessment (NGRA) is defined as an exposure-led, hypothesis-driven risk assessment approach that integrates in silico, in chemico and in vitro approaches.

Joint EFSA/ECHA guidance document for the identification of endocrine disruptors under EU Biocides and Pesticides Regulation

The European Food Safety Authority (EFSA) and the European Chemical Agency (ECHA) jointly published in June 2018 the long-awaited guidance for the identification of endocrine disruptors.

Read-across – State of the art and next level!

In light of the limitations of existing non-animal based hazard assessment methodologies particularly for systemic endpoints, read-across is currently considered to be the most applicable strategy in the short- to medium-term in support of innovation.