EFSA/ECHA (2018) guidance for the identification of endocrine disruptors (ED): looking back after the first 3 years of implementation

Initial reflections on a way forward to update the REACH Annexes in relation to endocrine disruption properties – OPEN FOR FEEDBACK UNTIL 16 NOVEMBER

The European Commission is looking for comments on its intention to update REACH data requirements for identifying and assessing endocrine […]

Endocrine disruptors – Recent policy developments and recommendations in the EU

In recent years, the Commission has taken steady actions and acted against EDs in line with the different requirements laid down in the relevant legislation. However, substances with endocrine disrupting properties are subject to case-by-case regulatory action on the basis of the general requirements of the legislation.

Developments on the identification of potential endocrine disruptors under EU legislation

Introducing 2018 developments in EU policy and legislation on endocrine disruptors and our first experiences with the EFSA/ECHA guidance.

Inhalation exposure and risk assessment associated with the release of VOC, SVOC and particulates from scented candles

ToxMinds assessed consumer exposures and risks associated with the release of volatile organic compounds, including benzene, formaldehyde and naphthalene from scented candles.

Identification of hazards associated with non-intentionally added substances in a food contact polymer

ToxMinds was tasked by a petrochemical company to assess the toxicological hazard of and derive MRLs for non-intentionally added substances in a food contact polymer.

Development of permissible daily exposure levels of impurities present in pharmaceutical products

ToxMinds is a key resource to a major multinational biopharmaceutical company on the safety assessment of extractables & leachables and manufacturing impurities ending up in the medicinal product.

Human health risk assessment of a biocidal product line for due diligence purposes

ToxMinds supported the acquisition of a biocidal product line by a multinational consumer product company by demonstrating the safety of the products for children and adults under in-use conditions.

Feasibility screening of new molecules to be used in cosmetic applications

ToxMinds supports a large, multinational cosmetic product manufacturer in prioritising new molecules for use in cosmetic applications from a consumer safety point of view.

Evaluation of skin sensitisation potential of a class of functionalised chemicals on the basis of in silico, in vitro and in vivo data

ToxMinds assessed and evaluated the skin sensitisation potential of functionalised chemicals on the basis of in silico, in vitro and in vivo data.

Identification of safe exposure levels of ingredients used in cosmetic and consumer products

ToxMinds supported a large multinational consumer product company in the context of an internal chemical safety review programme by developing standardised hazard assessments.

Endocrine disruption

Joint EFSA/ECHA guidance document for the identification of endocrine disruptors under EU Biocides and Pesticides Regulation

The European Food Safety Authority (EFSA) and the European Chemical Agency (ECHA) jointly published in June 2018 the long-awaited guidance for the identification of endocrine disruptors.